MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. Popular applications include:
  • Predisposition to Cancer
  • Neuromuscular Disorders
  • Intellectual Disability
  • Solid Tumours

News

▷ New protocol versions available
As of 17 April 2018, new versions of the MLPA General Protocol and the MS-MLPA General Protocol have been published online. You can find the new versions on the MLPA Protocols page. Both protocols have been reorganized and rewritten. The most important changes can be found in the document history on page 2 of each protocol.

▷ MRC-Holland to Supply HhaI enzyme
Important news for MS-MLPA users: MRC-Holland has launched its own restriction enzyme SALSA HhaI. The HhaI enzyme – an essential component of MS-MLPA reactions – was developed to ensure that every aspect of MLPA, from start to result interpretation, is of the highest standards.

A free vial of SALSA HhaI enzyme (item number: SMR51) will be included with all orders containing an MS-MLPA probemix from 3 April until 30 September 2018. More information can be found here.

MLPA Workshops
MLPA workshop figure

To increase your understanding of MLPA, MRC-Holland continues to organize one-day MLPA workshops. During the theoretical and practical sessions, participants learn how to get the most out of their MLPA data from setting up the experiment to the result interpretation and troubleshooting.

Check out our destinations for 2018 on our Support Portal!

Support Portal
Do you have a technical question about MLPA or Coffalyser.Net? Visit our Support Portal for support-related content such as:
  • troubleshooting guidance;
  • knowledgebase articles (FAQ);
  • instruction videos;
  • e-learning modules;
  • manuals & other downloads.

You can also contact us directly from the portal, and optionally view and manage your correspondence with our Technical Support department.

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new products
P451-Chromosome 16
Breast cancer + various tumour types
P476-ZNRF3
Adrenocortical tumours and other solid tumours
improved products
P253-NB mix 3
Neuroblastoma
P252-NB mix 2
Neuroblastoma
P056-TP53
Li-Fraumeni syndrome (LFS) and tumour analysis
P175-Tumour Gain
Tumour Gain
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